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Current studies still commonly face limitations in causal inference and model systems: most findings are derived from in vitro induction systems or single animal models, making it difficult to simultaneously resolve the coordinated influence of tissue substrate availability, intercellular metabolic division of labor, and local cytokine networks on metabolic pathways

Although amino acids are often shown in textbooks as the right-hand structure, they actually mostly exist as the left-hand structure

PMID 29109518

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